期刊
COORDINATION CHEMISTRY REVIEWS
卷 354, 期 -, 页码 169-181出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2017.07.009
关键词
Aminopeptidase; Enzyme targeting; Glutamyltranspeptidase; Near-infrared fluorophore; Penicillin amidase; Protease
资金
- Natural Sciences and Engineering Council of Canada
- National Research Foundation of Korea [NRF 2017-R1A2B4006706]
Near-infrared (NIR) fluorescent probes possess a characteristic molecular structure with a highly conjugated polyene or polynuclear system, thus exhibiting a long emission wavelength over 650 nm up to 900 nm. They are of increasing interest owing to their capability of deep tissue penetration as well as low spectral interference with biomolecules in the living system. In this review, we will examine typical molecular structures of NIR fluorophores and then describe their enzymatic reactions with peptidases from the viewpoint of chemical design and reaction mechanism. The targeting enzymes will be covered from aminopeptidase, glutamyltranspeptidase, protease to penicillin G-amidase. Further application to tumor imaging and therapy is also discussed as a theranostic approach. (C) 2017 Elsevier B.V. All rights reserved.
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