4.8 Review

The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions

期刊

COORDINATION CHEMISTRY REVIEWS
卷 360, 期 -, 页码 17-33

出版社

ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2018.01.009

关键词

Platinum drugs; Metal-based compounds; Cancer chemotherapy; DNA adducts; Molecular tumour targets

向作者/读者索取更多资源

Platinum drugs are extensively used in the clinic to treat cancer, often leading to a palliative response rather than a cure. While DNA is considered to be the primary target of platinum drugs, there is no clear relationship between cellular platinum accumulation, DNA platination and Pt-DNA adduct removal, and herein we describe new mechanistic insights of platinum drugs related to the hallmarks of cancer and how they interfere with the tumour microenvironment. We then proceed to describe the properties of other metal drugs, including both non-targeted compounds that do not significantly interact with DNA and targeted compounds that interfere more selectively with specific pathways responsible for tumour growth and invasion. Our analysis of the cancer biology and the selected drugs allows us to propose possible routes for future drug development based on metal scaffolds. (C) 2018 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据