γδ T cells in cancer

With the promise of T cell-based therapy for cancer finally becoming reality, this Review focuses on the less-studied gamma delta T cell lineage and its diverse responses to tumours gamma delta T cells have well-established protective roles in cancer, largely on the basis of their potent cytotoxicity and interferon-gamma production. Besides this, recent studies have revealed a series of tumour-promoting functions that are linked to interleukin-17-producing gamma delta T cells. Here, we integrate the current knowledge from both human and mouse studies to highlight the potential of gamma delta T cell modulation to improve cancer immunotherapy.