期刊
BIOMEDICAL REPORTS
卷 3, 期 5, 页码 617-620出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2015.481
关键词
cytotoxicity; biocompatibility; medical devices; xCELLigence
资金
- Youth Development Research Foundation of National Institutes for Food and Drug Control [2013WC1]
The cytotoxicity test is one of the biological evaluation and screening tests that use tissue cells in vitro to observe the cell growth, reproduction and morphological effects by medical devices. Cytotoxicity is preferred as a pilot project test and an important indicator for toxicity evaluation of medical devices as it is simple, fast, has a high sensitivity and can save animals from toxicity. Three types of cytotoxicity test are stated in the International Organization for Standardization 109993-5: Extract, direct contact and indirect contact tests. The xCELLigence real-time cell analysis system shows a significant potential in regards to cytotoxicity in recent years. The present review provides a brief insight into the in vitro cytotoxicity testing of medical devices.
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