期刊
JOURNAL OF PSYCHOACTIVE DRUGS
卷 47, 期 4, 页码 331-335出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/02791072.2015.1073412
关键词
biochemical validation; self-report; smokeless tobacco users; urine; varenicline
资金
- National Institute on Drug Abuse [R21 DA026404, R01 DA025078]
- National Institute on Drug Abuse and National Cancer Institute [P50 CA143187]
- National Cancer Institute
- National Institute of General Medical Sciences
- National Human Genome Research Institute [U01 DA020830]
- National Cancer Institute [P30 CA916520]
The validity of self-reported tobacco use is often questioned given the potential for underestimation of use. This study used data from a double-blind, placebo-controlled clinical trial of varenicline for smokeless tobacco dependence in India to evaluate the accuracy of self-reported smokeless tobacco cessation using biochemical validation procedures and to evaluate correlates of reporting inaccuracy. Smokeless tobacco users attending a dental clinic at AIIMS were randomized to placebo or varenicline; all participants received counseling. Detailed smokeless tobacco use was recorded and abstinence was defined as cotinine-verified 7-day point prevalence cessation (cotinine<50ng/ml) and breath CO>10ppm at the end of 12weeks of treatment. One-half of study completers (82/165) self-reported abstinence. Biochemical verification confirmed that (65.9%) subjects provided accurate self-reports while (34.1%) participants underreported tobacco use. These data indicate poor agreement between self-reported and biochemically confirmed abstinence (=-0.191). Underreporters of tobacco use had significantly higher baseline cotinine (p<0.05), total craving (p<0.012), and negative reinforcement craving (p<0.001) vs. those whose self-reports were correctly verified. These findings provide evidence to support the need for biochemical validation of self-reported abstinence outcomes among smokeless tobacco users in cessation programs in India and identify high levels of pretreatment cotinine and craving levels as potential correlates of false reporting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据