期刊
FOOD RESEARCH INTERNATIONAL
卷 69, 期 -, 页码 114-120出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.foodres.2014.12.015
关键词
Amphiphilic chitosan; Nanoliposome; Dextran sulfate; EGCG; In vitro digestion stability; Sustaining release
资金
- National Science Foundation of China [21266021]
- Research Program of State Key Laboratory of Food Science and Technology, Nanchang University [SKLF-ZZB-201311]
A novel delivery system was developed by coating dextran sulfate (DS) on the surface of amphiphilic chitosan derivative nanoliposome (DCMC-NL) through electrostatic interaction. DS coated DCMC-NL (DS-DCMC-NL) exhibited larger average particle size, lower polydispersity index, and more negative zeta potential, compared with DCMC-NL DS-DCMC-NL exhibited good in vitro digestion stability, with no obvious variations on particle size under gastrointestinal tract environment, while DCMC-NL immediately formed sediment after being mixed with simulated intestinal fluid (SIF). EGCG as a hydrophilic model drug was encapsulated in DS-DCMC-NL, with a high encapsulation efficiency (90.8%). EGCG loaded DS-DCMC-NL (EG-DS-DCMC-NL) exhibited a relative good sustaining release property. The degradation of EGCG during SIF was effectively slowed by the encapsulation with DS-DCMC-NL This study expects to provide a promising carrier for further application of EGCG. (C) 2014 Elsevier Ltd. All rights reserved,
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