期刊
ENDOCRINE
卷 50, 期 2, 页码 413-423出版社
SPRINGER
DOI: 10.1007/s12020-015-0572-3
关键词
Uncoupling protein 1; Perirenal adipose tissue; Hypertension
资金
- National Natural Science Foundation of China [81170796, 81370950]
- Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU [20113012]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Natural Science Youth Foundation of China [30900504]
The objective of this study is to determine the property of human perirenal adipose tissue (PAT) and assess the adipose property of PAT in hypertension. Ninety-four patients, including 64 normotensive patients (T-NP) and 30 hypertensive patients (HP), who underwent renal surgery were included. Expression analysis was performed using quantitative real-time polymerase chain reaction, Western blot, and immunohistochemistry in PAT and back subcutaneous adipose tissue (bSAT) depots. Compared with bSAT, PAT adipocytes were smaller, and the expressions of uncoupling protein-1 (UCP1) mRNA and protein were markedly higher, while the mRNA expressions of markers for classic beige and white adipocytes were lower in PAT. Immunohistochemistry analysis showed more multilocular UCP1-positive adipocytes in PAT than in bSAT. UCP1 expressions were lower in PAT in HP than in the T-NP or age- and body mass index-matched NP groups. Bigger unilocular adipocytes with less UCP1 staining in PAT were detected in HP than in NP group, although no such difference was observed in bSAT. PAT acts as a brown-like fat. UCP1 expression of PAT was lower in HP than in normotensive patients. UCP1 expression of PAT may serve as a protective indicator for hypertension.
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