期刊
PHYSIOLOGICAL REPORTS
卷 3, 期 12, 页码 -出版社
WILEY
DOI: 10.14814/phy2.12647
关键词
Cerebral atrophy; cerebral vascular reactivity; high altitude
类别
资金
- Natural Sciences and Engineering Research Council (NSERC) of Canada [249990]
- Canada Research Chair
- NSERC
- Heart and Stroke Foundation of Canada
- Canadian Stroke Network
- Canadian Institutes of Health Research (CIHR) Institute of Circulatory and Respiratory Health
- CIHR Institute of Aging
- Michael Smith Foundation for Health Research
- CIHR New Investigator Award
- Woolf Fisher scholarship
Although high-altitude exposure can lead to neurocognitive impairment, even upon return to sea level, it remains unclear the extent to which brain volume and regional cerebral vascular reactivity (CVR) are altered following high-altitude exposure. The purpose of this study was to simultaneously determine the effect of 3 weeks at 5050 m on: (1) structural brain alterations; and (2) regional CVR after returning to sea level for 1 week. Healthy human volunteers (n = 6) underwent baseline and follow-up structural and functional magnetic resonance imaging (MRI) at rest and during a CVR protocol (end-tidal PCO2 reduced by -10, -5 and increased by +5, +10, and +15 mmHg from baseline). CVR maps (% mmHg(-1)) were generated using BOLD MRI and brain volumes were estimated. Following return to sea level, whole- brain volume and gray matter volume was reduced by 0.4 +/- 0.3% (P < 0.01) and 2.6 +/- 1.0% (P < 0.001), respectively; white matter was unchanged. Global gray matter CVR and white matter CVR were unchanged following return to sea level, but CVR was selectively increased (P < 0.05) in the brainstem (+30 +/- 12%), hippocampus (+12 +/- 3%), and thalamus (+10 +/- 3%). These changes were the result of improvement and/or reversal of negative CVR to positive CVR in these regions. Three weeks of high-altitude exposure is reflected in loss of gray matter volume and improvements in negative CVR.
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