期刊
CLINICAL AND MOLECULAR HEPATOLOGY
卷 21, 期 4, 页码 319-325出版社
KOREAN ASSOC STUDY LIVER
DOI: 10.3350/cmh.2015.21.4.319
关键词
iNOS; NO; Liver sinusoidal endothelial cell; Hepatic stellate cell; Kupffer cell
资金
- NIH [R01 DK082600, P30 DK045735, R21AA023599]
The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.
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