期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 169, 期 -, 页码 151-159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.04.056
关键词
Chitosan-g-eugenol; Zwitterionic copolymer; Electrospun membrane; Antibacterial activity; Antifouling activity
资金
- Natural Science Foundation of Tianjin, China [17JCZDJC37500]
- National Natural Science Foundation of China [51473118]
Integrated antibacterial and antifouling surfaces in favor of avoiding implant-related infections are necessarily required for biomaterials when they contact with the body fluid. In this work, an antibacterial and antifouling membrane was developed via cross-linking chitosan-g-eugenol and the zwitterionic copolymer poly(sulfobetaine methylacrylate-co-2-aminoethyl methacrylate) on the electrospun poly carbonate urethane substrate using genipin as a cross-linker. Antibacterial assays demonstrated that the prepared membranes had efficient antibacterial activity with 92.8 2.5% and 95.2 1.3% growth inhibition rates against Escherichia coli and Staphylococcus aureus, respectively. The investigations on antifouling activity and hemocompatibility of the membranes showed significant resistances to bacterial attachment, non-specific protein adsorption and platelet adhesion, and presented lower hemolytic activity and good anticoagulant activity as well. Moreover, cell culture assays indicated that the prepared membranes exerted no obvious cytotoxicity with more than 80% of relative L929 fibroblast viability. Therefore, the membranes with integrated antibacterial and antifouling properties could be potentially applied in promising indwelling devices. (C) 2018 Elsevier B.V. All rights reserved.
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