期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 167, 期 -, 页码 318-327出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.04.028
关键词
Biological behavior; Bone graft; Calcium phosphate; Strontium; Compressive strength
资金
- National Natural Science Foundation of China [31500770]
- Pearl River S&T Nova Program of Guangzhou [201710010149]
- Science and Technology Program of Guangzhou City of China [201508020017]
- Fundamental Research Funds for the Central Universities
- Guangdong Natural Science Funds for Distinguished Young Scholar [2016A030306018]
beta-tricalcium phosphate (beta-TCP) is well known as a resorbable bone repair material due to its inherent excellent biocompatibility and osteoconductivity. However, beta-TCP is encountered with osteostimulation-deficiency and poor mechanical strength because of poor sinterability. Herein, we prepared novel beta-TCP composite ceramics (TCP/SPGs) by introducing strontium-containing phosphate-based glass (SPG; 45P(2)O(5)-32SrO-23Na(2)O) as sintering additive. The SPG helped to achieve efficient liquid-phase sintering of beta-TCP at 1100 degrees C. The compressive strength of TCP/SPGs with 15 wt.% SPG (TCP/SPG15) was 2.65 times as high as that of plain beta-TCP ceramic. The SPG reacted with beta-TCP, and the Sr2+ and Na2+ from SPG replaced Ca2+ in the lattice structure of beta-TCP, enabling the sustained release of strontium from TCP/SPGs. In vitro cytological test indicated that TCP/SPGs with certain amount of SPG were highly biocompatible, and noticeably promoted osteogenesis, and inhibited osteoclastic activities. Our results suggested that the TCP/SPG15 might be potential high-strength bone grafts used for bone defect repair, especially in the osteoporotic condition. (C) 2018 Elsevier B.V. All rights reserved.
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