期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 162, 期 -, 页码 398-404出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2017.11.037
关键词
Gold nanoflowers; Acanthopanacis cortex; Green synthesis; Inflammation
资金
- Next Generation BioGreen 21 Program, Rural Development Administration, Republic of Korea [PJ0120342016]
We reported the rapid synthesis (<8 s) of gold nanoparticles at room temperature using Acanthopanacis cortex extract (A-AuNPs). We characterized the A-AuNPs using several analytical techniques and found that nano-flower type A-AuNPs, which are known to possess a coarse surface with a high surface to volume ratio, conferring these particles with high binding capacity for various biological molecules. After confirming the stability of the nanoparticles, we investigated the anti-inflammatory effect of A-AuNPs in LPS-stimulated RAW264.7 cells. These nanoparticles inhibited LPS-induced iNOS and COX-2 protein as well as gene expression level, along with reduction of NO and PGE(2) production. Furthermore, we observed that the A-AuNPs inhibited translocation of NF-kappa B and AP-1 through phosphorylation of MAPK signaling by western blot analysis. In summary, we synthesized gold nanoflowers in an economical and eco-friendly way using Acanthopanacis cortex extract and the resultant flower-like A-AuNPs had anti-inflammatory activity, highlighting their potential as therapeutic candidates for suppression of inflammatory-mediated diseases. (C) 2017 Elsevier B.V. All rights reserved.
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