期刊
CLINICAL TRANSPLANTATION
卷 32, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/ctr.13190
关键词
classification systems; delayed graft function; donors and donation: deceased; graft survival; DGF; KDPI; kidney donor profile index; kidney transplant
资金
- Foundation for the National Institutes of Health
- American Society of Transplant Surgeons
IntroductionRenal transplant outcomes result from a combination of factors. Traditionally, donor factors were summarized by classifying kidneys as extended criteria or standard criteria. In 2014, the nomenclature changed to describe donor factors with the kidney donor profile index (KDPI). We aim to evaluate the relationship between KDPI and delayed graft function (DGF), and the impact KDPI on transplant outcomes for both donor after cardiac death (DCD) and donor after brain death (DBD). MethodsAn IRB-approved single-center retrospective chart review was performed from January 1999 to July 2013. The patients were divided into six groups: DBD KDPI 60, DBD KPDI 61-84, DBD KDPI 85, DCD KDPI 60, DCD KPDI 61-84, and DCD KDPI 85. Rates of DGF, patient survival, and graft survival were examined among groups. ResultsA total of 2161 kidney transplants were included. DGF rates increased, and graft and patient survival decreased with increasing KDPI (P<.001). DCD kidneys had higher DGF rates than their DBD counterparts (P<.001). In DCD kidneys, a higher KDPI score did not significantly affect the DGF rates (P>.302). There was no significant difference in graft or patient survival in all-comers when comparing DCD and DBD kidneys with equivalent KDPIs (P>.317). Patients with DGF across all categories demonstrated worse graft half-lives. ConclusionThe KDPI system is an accurate predictor of donor contributions to transplant outcomes. Recipients of DBD kidneys experience an increase in the rate of DGF as their KDPI increases. DCD kidneys have higher DGF rates than their DBD counterparts with similar KDPIs. Patients with documented post-transplant DGF had between 3- and 5-year shorter graft half-lives when compared to recipients that did not experience DGF. Initiatives to reduce the rate of DGF could provide a significant impact on graft survival and result in a reduction in the number of patients requiring retransplant.
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