期刊
CLINICAL SCIENCE
卷 132, 期 9, 页码 909-923出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20171592
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资金
- Institut National de la Sante et de la Recherche Medicale, Fondation de France [2014-00047968]
- ANR MRFOCUS [ANR-15-CE14-0032-02]
- Fight-HF Avenir investment program [ANR-15-RHUS-0004]
- Region Ile de France CORDDIM
- Agence Nationale de la Recherche (ANR) [ANR-15-CE14-0032] Funding Source: Agence Nationale de la Recherche (ANR)
Neutrophil gelatinase-associated lipocalin (NGAL) is a small circulating protein that is highly modulated in a wide variety of pathological situations, making it a useful biomarker of various disease states. It is one of the best markers of acute kidney injury, as it is rapidly released after tubular damage. However, a growing body of evidence highlights an important role for NGAL beyond that of a biomarker of renal dysfunction. Indeed, numerous studies have demonstrated a role for NGAL in both cardiovascular and renal diseases. In the present review, we summarize current knowledge concerning the involvement of NGAL in cardiovascular and renal diseases and discuss the various mechanisms underlying its pathological implications.
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