期刊
CLINICAL REHABILITATION
卷 32, 期 10, 页码 1299-1307出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269215518779122
关键词
Pulmonary rehabilitation; idiopathic pulmonary fibrosis; exercise capacity; health-related quality of life
资金
- Medical Scientific Research Projects Foundation of Chongqing [2017MSXM034]
Objective: To investigate the short- and long-term effects of pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis (IPF). Data sources: An electronic search of MEDLINE, Embase and Cochrane Central databases along with hand search of relevant papers were performed on 15 March 2018. Review methods: This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched the literature for randomized controlled trials of pulmonary rehabilitation in IPF patients. The outcomes were exercise capacity and health-related quality of life. Two authors independently extracted data, assessed trial eligibility and risk of bias. Meta-analyses were performed using RevMan and STATA software. Results: We extracted data from four randomized controlled trials (142 participants). At short-term follow-up, pulmonary rehabilitation significantly enhanced 6-minute walk distance (6-MWD; weighted mean difference (WMD)=38.38, 95% confidence interval (CI)=4.64-72.12, I-2=60.7%; P<0.05), reduced St. George's Respiratory Questionnaire (SGRQ)/IPF-specific SGRQ (SGRQ-I) total score (WMD=-8.40, 95% CI=-11.44 to -5.36, I-2=0%; P<0.00001). At long-term follow-up, pulmonary rehabilitation could not enhance 6-MWD (WMD=17.02, 95% CI=-26.87 to 60.81, I-2=36.3%; P=0.43) or reduce SGRQ/SGRQ-I total score (WMD=-3.45, 95% CI=-8.55 to 1.64, I-2=38.3%; P=0.088). Conclusion: In patients with IPF, pulmonary rehabilitation showed short-term effects in enhancing exercise capacity and health-related quality of life, while it had no detectable effects at long-term follow-up.
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