期刊
FOOD CHEMISTRY
卷 185, 期 -, 页码 383-388出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2015.03.152
关键词
Cranberries; 3T3-L1 cells; Lipogenesis; Leptin; Adiponectin
资金
- European Regional Development Fund [01.01.02-00-061/09]
It has previously been shown that lyophilized cranberries (LCB) decreased lipid accumulation in 3T3-L1 cells and inhibited preadipocyte differentiation by down-regulation of the expression of key transcription factors (PPAR gamma, C/EBP alpha , SREBP1) of the adipogenesis pathway. To elucidate the molecular basis of anti-lipogenic activity of LCB, the expression of several genes involved in lipid metabolism, such as adipocyte fatty acid-binding protein (aP2), lipoprotein lipase (LPL), fatty acid synthase (FAS), hormone sensitive lipase (HSL) and perilipin 1 (PLIN1), was examined in the present study. Additionally, the effects of LCB on adiponectin and leptin expression and protein secretion were also investigated. LCB reduced lipid accumulation during preadipocyte differentiation by down-regulation of the mRNA level of aP2, FAS, LPL, HSL and PLIN1. Moreover, LCB decreased leptin gene expression and increased adiponectin gene expression and protein secretion in a dose-dependent manner. Therefore cranberries could be considered as bioactive factors, which are effective in the inhibition of adipose tissue mass production. (C) 2015 Elsevier Ltd. All rights reserved.
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