期刊
FOOD CHEMISTRY
卷 168, 期 -, 页码 167-175出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2014.06.100
关键词
Chlorogenic acid; Caffeic acid; IL-8; Dextran sulphate sodium; Colitis
Chlorogenic acid (CHA) is an antioxidant polyphenol prevalent in human diet, with coffee, fruits, and vegetables being its main source. Effects of CHA and CHA metabolites were evaluated on the IL-8 production in human intestinal Caco-2 cells induced by combined stimulation with tumour necrosis factor alpha (TNF alpha) and H2O2. CHA and caffeic acid (CA) inhibited TNF alpha- and H2O2-induced IL-8 production. We also examined the in vivo effects of CHA and CA using dextran sulphate sodium (DSS)-induced colitis in mice. CHA attenuated DSS-induced body weight loss, diarrhea, fecal blood, and shortening of colon and dramatically improved colitis histological scores. Furthermore, increases in the mRNA expression of colonic macrophage inflammatory protein 2 and IL-1 beta, which were induced by DSS, were significantly suppressed by CHA supplementation. These results suggest that dietary CHA use may aid in the prevention of intestinal inflammatory conditions. (C) 2014 Elsevier Ltd. All rights reserved.
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