期刊
ANALYTICAL CHEMISTRY INSIGHTS
卷 10, 期 -, 页码 17-22出版社
SAGE PUBLICATIONS LTD
DOI: 10.4137/ACI.S25554
关键词
methadone; EDDP; GC MS; human plasma
This study aimed to develop a solid-phase extraction gas chromatography-selected ion monitoring-mass spectrometry method for the determination of methadone (MDN) and 2-ethylidene-1,5-dimethy4-3,3-dipherwlpyrrolidirie (EDDP) in human plasma. The linear response was obtained in over the concentration range from 10 to 2000 ng/mL for MDN and EDDP The absolute recoveries of MDN and EDDP Were 95.9%-98.93v and 94.8%-102.4%, with relative standard deviation (RSD) ranging from 1.8% to 2.7% and 1.80/6 to 3.90/6, respectively. The intra- and interday precisions were found to be less than 5% for both an Is The limits of deteetion of MDN and EDDP were 4 and 5 ng/mL, respectively. The presented method was convenient for therapeutic drug monitoring and pharmacokinetic studies in patients on heroin-assisted MDN therapy.
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