期刊
CLINICAL NUTRITION
卷 37, 期 4, 页码 1332-1339出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2017.06.003
关键词
Diet quality; Inflammation; Ankle brachial blood pressure index; Subclinical vascular disease; Peripheral arterial disease; HCHS/SOL
资金
- Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research from the NIH-National Heart Lung and Blood Institute (NHLBI) [K01-HL120951]
- NHLBI [N01-HC65233, N01-HC65234, N01-HC65235, N01-HC65236, N01-HC65237]
- National Center on Minority Health and Health Disparities
- National Institute on Deafness and Other Communication Disorders
- National Institute of Dental and Craniofacial Research
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Neurological Disorders and Stroke
- Office of Dietary Supplements
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K01HL120951, R01HL065234, U01HL065233] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK020541] Funding Source: NIH RePORTER
Background & aims: Diet quality may influence non-traditional cardiovascular disease (CVD) risk factors - namely, C-reactive protein (CRP) and the ankle-brachial index (ABI). Pre-existing traditional cardiometabolic conditions may confound this association. We aimed to determine whether diet quality was associated with high-risk CRP or ABI, independently from traditional cardiometabolic risk factors. Methods: Baseline data were analyzed from US-Hispanics/Latinos aged 18-74 y without previously-diagnosed CVD participating in the population-based Hispanic Community Health Study/Study of Latinos cohort. Included were 14,623 participants with CRP data, and 7892 participants (>= 45 y) with ABI data. Diet quality was measured with the Alternate Healthy Eating Index (AHEI). Results: Nearly 35% of Hispanics/Latinos had high-risk CRP concentration and 6.3% had high-risk ABI (peripheral artery disease (PAD): 4.2%; arterial stiffness: 2.1%). After adjusting for sociodemographic and lifestyle factors, diabetes, hypertension, hypercholesterolemia, and obesity, the odds (95% confidence interval) of having high-risk ABI were 37% (5, 44%) lower per 10-unit increase in AHEI (p = 0.018). The association was marginally significant for PAD (0.77 (0.58,1.00); p = 0.05), and non significant for arterial stiffness (p = 0.16). Each 10-unit increase in AHEI was associated with 21% (10, 30%) lower odds of high-risk CRP (p = 0.0002) after similar adjustments. There were no significant interactions between AHEI and age, sex, ethnicity, smoking, or pre-existing cardiometabolic conditions for associations with ABI. The association between AHEI and high-risk CRP was stronger for those with diabetes (p-interaction < 0.0001), obesity (p-interaction = 0.005), or ages 45-74 y (p-interaction = 0.011). Conclusions: Higher diet quality is associated with lower inflammation and less adverse ABI among Hispanics/Latinos, independently from traditional cardiometabolic risk factors. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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