期刊
CLINICAL NEUROPHYSIOLOGY
卷 129, 期 3, 页码 676-686出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2017.10.036
关键词
Implant effect; ECoG; Intracranial monitoring; Responsive stimulation; Epilepsy
Objective: Subacute and long-term electrocorticographic (ECoG) changes in ambulatory patients with depth and cortical strip electrodes were evaluated in order to determine the length of the implant effect. Methods: ECoG records were assessed in patients with medically intractable epilepsy who had depth and/or strip leads implanted in order to be treated with brain-responsive stimulation. Changes in total spectral power, band-limited spectral power, and spike rate were assessed. Results: 121 patients participating in trials of the RNS (R) System had a total of 93994 ECoG records analyzed. Significant changes in total spectral power occurred from the first to second months after implantation, involving 55% of all ECoG channels (68% of strip and 47% of depth lead channels). Significant, but less pronounced, changes continued over the 2nd to 5th post-implant months, after which total power became more stable. Similar patterns of changes were observed within frequency bands and spike rate. Conclusions: ECoG spectral power and spike rates are not stable in the first 5 months after implantation, presumably due to neurophysiological and electrode-tissue interface changes. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd.
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