期刊
CLINICAL MEDICINE
卷 18, 期 2, 页码 155-159出版社
ROY COLL PHYS LONDON EDITORIAL OFFICE
DOI: 10.7861/clinmedicine.18-2-155
关键词
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资金
- Association of British Neurologists
- NIHR Health Protection Research Unit in Emerging and Zoonotic Infections
- National Institute for Health Research Programme Grants for Applied Research Programme [RP-PG-0108-10048]
- European Union [734584]
- MRC [MC_PC_15096, G116/194] Funding Source: UKRI
Encephalitis, inflammation of the brain, is most commonly caused by a viral infection (especially herpes simplex virus [HSV] type 1 in the UK) although autoimmune causes, such as N-methyl D-aspartate receptor (NMDAR) antibody encephalitis, are increasingly recognised. Most patients present with a change in consciousness level and may have fever, seizures, movement disorder or focal neurological deficits. Diagnosis hinges crucially on lumbar puncture and cerebrospinal fluid (CSF) examination, but imaging and electroencephalography (EEG) may also be helpful. Treatment of HSV encephalitis with aciclovir dramatically improves outcome, but the optimal management of autoimmune encephalitis is still uncertain. Many patients with encephalitis are left with residual physical or neuropsychological deficits which require long-term multidisciplinary management. Here we review assessment of patients with suspected encephalitis, general aspects of management and areas of ongoing research.
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