期刊
CLINICAL LABORATORY
卷 64, 期 4, 页码 515-525出版社
CLIN LAB PUBL
DOI: 10.7754/Clin.Lab.2017.171026
关键词
microRNA; bladder cancer; LASS2; cell biology; epithelial mesenchymal transition; chemosensitivity
资金
- National Natural Science Foundation of China [81460384, 81660422, 81660423]
- Joint Project of Science and Technology, Department of Yunnan and Kunming Medical University [2014FA015, 2014FZ031]
- Project of Yunnan Provincial Science and Technology [2015FB196]
- Doctor Newcomer Award of Yunnan Province
Background: Hsa-miR-3658 is upregulated in various tumors, but its expression in bladder cancer has been rarely studied. Methods: In this study, hsa-miR-3658 expressions in several bladder cancer cell lines were examined, and its effect on the malignant degree of bladder cancer and whether hsa-miR-3658 regulates tumor biological behaviors through LASS2 and its downstream molecular pathway were studied and validated. Results: It was found miR-3658 expressions differed among different cell lines, which may be an influence factor on the malignancy. MiR-3658 can enhance the proliferation, migration and invasion of bladder cancer cells, inhibit cell adhesion and reduce cell chemosensitivity. MiR-3658 can promote the epithelial-mesenchymal transition of bladder cancer cells through the molecular mechanism of affecting the expressions of epithelial-mesenchymal transition marker protein and related transcription factors. Conclusions: MiRNA-3658 is upregulated in bladder cancer cells, and this change is associated with the proliferation, invasion and resistance of bladder cancer cells. The effect of miR-3658 on bladder cancer cell biology may be associated with the effect on LASS2.
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