期刊
CLINICAL INFECTIOUS DISEASES
卷 67, 期 4, 页码 628-638出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciy190
关键词
typhoid fever; Salmonella enterica serovar Typhi; Salmonella enterica serovar Paratyphi; mortality; antimicrobial resistance
资金
- Bill & Melinda Gates Foundation [OPP1116967]
- Research Foundation-Flanders (FWO)
- Belgian American Educational Foundation
- Antwerp Study Centre for Infectious Diseases, University of Antwerp
- Bill and Melinda Gates Foundation [OPP1116967] Funding Source: Bill and Melinda Gates Foundation
Enteric fever is a febrile illness, occurring mostly in Asia and Africa, which can present as a severe and possibly fatal disease. Currently, a case fatality rate (CFR) of 1% is assumed when evaluating the global burden of enteric fever. Until now, no meta-analysis has been conducted to summarize mortality from enteric fever. Therefore, we conducted a systematic review and meta-analysis to aggregate all available evidence. We estimated an overall CFR of 2.49% (95% confidence interval, 1.65%-3.75%; n = 44), and a CFR in hospitalized patients of 4.45% (2.85%-6.88%; n = 21 of 44). There was considerably heterogeneity in estimates of the CFR from individual studies. Neither age nor antimicrobial resistance were significant prognostic factors, but limited data were available for these analyses. The combined estimate of the CFR for enteric fever is higher than previously estimated, and the evaluation of prognostic factors, including antimicrobial resistance, urgently requires more data.
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