期刊
CLINICAL IMMUNOLOGY
卷 196, 期 -, 页码 59-63出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2018.04.002
关键词
Immune senescence; Inflammation; Autoimmunity; Epigenetics
类别
资金
- NIH [AG020628, AG024824, AI110502]
- Geriatrics Research, Education and Clinical Care Center (GRECC) of the VA Ann Arbor Healthcare System
Aging of the immune system in humans and animals is characterized by a decline in both adaptive and innate immune responses. Paradoxically, aging is also associated with a state of chronic inflammation (inflammaging) and an increased likelihood of developing autoimmune diseases. Epigenetic changes in non-dividing and dividing cells, including immune cells, due to environmental factors contribute to the inflammation and auto immunity that characterize both the state and diseases of aging. Here, we review the epigenetic mechanisms involved in the development of immune senescence and autoimmunity in old age.
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