期刊
PAKISTAN JOURNAL OF MEDICAL SCIENCES
卷 31, 期 5, 页码 1201-1206出版社
PROFESSIONAL MEDICAL PUBLICATIONS
DOI: 10.12669/pjms.315.6925
关键词
Sepsis; Mortality; Gender; Cytokines; Interleukin-10; Interleukin-6; TNFa
资金
- Aga Khan University Research Council [051F420YY]
Background and Objective: Sepsis remains a leading cause of death across the world, carrying a mortality rate of 20-50%. Women have been reported to be less likely to suffer from sepsis and to have a lower risk of mortality from sepsis compared to men. The objective of this study was to determine the relationship between gender and mortality in sepsis, and compare cytokine profiles of mate and female patients. Methods: This was a prospective case series on 97 patients admitted with sepsis. Clinical and microbiological data was gathered, blood samples were collected for cytokine (IL-10, IL-6 and TNFa) levels and patients were followed up for clinical outcome. Results: There were 54% mates and 46% females, with no significant difference of age or comorbids between genders. Respiratory tract infection was the commonest source of sepsis, and was more common in females (60%) compared to males (39%) (p=0.034). Males had a higher mortality (p=0.048, RR 1.73) and plasma IL-6 level(p=0.040) compared to females. Mean IL-6 plasma level was significantly (p<0.01) higher in patients who died vs. who recovered. Conclusion: Our study shows that males with sepsis have a 70% greater mortality rate, and mortality is associated with a higher IL-6 plasma level.
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