期刊
CLINICAL CANCER RESEARCH
卷 24, 期 13, 页码 3036-3045出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-17-2257
关键词
-
类别
资金
- National Health and Medical Research Council of Australia
- University of Sydney's Sydney Research Excellence Initiative grant
Purpose: Therapeutic blockade of immune checkpoints has revolutionized cancer treatment. Durable responses, however, occur in less than half of those treated, and efforts to improve treatment efficacy are confounded by a lack of understanding of the characteristics of the cells that initiate antitumor immune response. Patients and Methods: We performed multiparameter flow cytometry and quantitative multiplex immunofluorescence staining on tumor specimens from immunotherapy-naive melanoma patients and longitudinal biopsy specimen obtained from patients undergoing anti-PD-1 therapy. Results: Increased numbers of CD69(+)CD103(+) tumor-resident CD8(+) T cells were associated with improved melanoma-specific survival in immunotherapy-naive melanoma patients. Local IL15 expression levels strongly correlated with these tumor-resident T-cell numbers. The expression of several immune checkpoints including PD-1 and LAG3 was highly enriched in this subset, and these cells significantly expanded early during anti-PD-1 immunotherapy. Conclusions: Tumor-resident CD8(+) T-cell numbers are more prognostic than total CD8(+) T cells in metastatic melanoma. In addition, they are likely to initiate response to anti-PD-1 and anti-LAG-3 treatments. We propose that the immune profile of these cells prior to treatment could inform strategies for immune checkpoint blockade. (C) 2018 AACR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据