Pharmacogenetics as Personalized Medicine: Association Investigation of SOD2 rs4880, CYP2C19 rs4244285, and FCGR2A rs1801274 Polymorphisms in a Breast Cancer Population in Iraqi Women

This study was carried out in Al-Diwanyah Teaching Hospital in the city of Qadisiyah in southern Iraq. The study was caused by the large and dangerous prevalence of breast cancer among Iraqi women. Samples of breast cancer patients as well as samples from healthy individuals were collected to compare the 2 groups on the basis of mutations in genes that cause breast cancer. Our study suggests that SOD2 rs4880 and CYP2C19 rs4244285 polymorphisms play an important role in development of breast cancer in an Iraqi population, and no significant association between FCGR2A rs1801274 and breast cancer. Background: Breast cancer is the most common cancer in women characterized by a high variable clinical outcome among individuals treated with targeted therapies. Patients and Methods: In this study, we performed a population-based approach intersecting high-throughput genotype data from Iraqi populations with publicly available pharmacogenomics information to estimate the frequency of genotypes correlated with responsiveness to breast cancer treatment thus improving the clinical management of this disease in an efficient and cost effective way. A total of 50 patients and 25 healthy controls were enrolled in our study. Genotyping of rs4880, rs4244285, and rs1801274 were examined in association with breast cancer in Iraqi women. Results: We found that individuals carrying the CT genotype of rs4880 manifested an increased risk of breast cancer compared with those carrying the TT genotype (odds ratio [OR], 0.171; 95% confidence interval [CI], 0.053-0.551; P = .002). In the dominant model, we observed that the CT and CC genotype of rs4880 showed an increased risk of breast cancer compared with the TT genotype (OR, 0.248; 95% CI, 0.089-0.690; P = .006). Moreover, subjects with the GA genotype of rs4244285 presented a higher risk of breast cancer than the GG genotype (OR, 0.256; 95% CI, 0.066-0.987; P = .038) and dominant models (OR, 0.025; 95% CI, 0.054-0.775; P = .013). Conclusion: The analysis revealed that rs1801274 showed linkage disequilibrium and decreased risk of breast cancer. In conclusion, our study suggests that rs4880 and rs4244285 polymorphisms play an important role in development of breast cancer in an Iraqi population, and no significant association was found between rs1801274 and the risk of breast cancer. (C) 2018 Elsevier Inc. All rights reserved.