期刊
CLINICAL AND EXPERIMENTAL HYPERTENSION
卷 41, 期 4, 页码 299-306出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10641963.2018.1469647
关键词
Protein Kinase D; vascular remodeling; hypertension
资金
- National Natural Science Foundation of China [81270175, 81670245]
The present study was designed to determine the role of PKD in vascular remodeling (VR) in Spontaneously hypertensive rats (SHRs). Increased SBP, VR and PKD activation were prominent in SHRs. The SBP has a positive correlation with the activation of PKD in SHRs. The ratio of media to lumen (MT/LD), volume fraction of collagen (VFC), hydroxyproline, IL-6, TNF-alpha and nitrotyrosine content were significantly related to the activated PKD. It may be concluded that PKD plays a central role in VR, and the mechanism may be related to its regulation of hypertrophy, fibrosis, inflammation and oxidative stress.
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