4.7 Review

Lipoprotein lipase: Biosynthesis, regulatory factors, and its role in atherosclerosis and other diseases

期刊

CLINICA CHIMICA ACTA
卷 480, 期 -, 页码 126-137

出版社

ELSEVIER
DOI: 10.1016/j.cca.2018.02.006

关键词

LPL; Lipoprotein; Triglyceride; Macrophages; Atherosclerosis

资金

  1. Canadian Institutes of Health Research [CIHR MOP-119511]
  2. National Natural Sciences Foundation of China [81300158]
  3. Aid Program for Science and Technology Department of Human Province [2015JC3083]
  4. Hunan province graduate student scientific research innovation project [CX2014B393, CX2016B485]
  5. Scientific Research Aid Program for Chinese Medicine of Human Province [201524]
  6. Zhengxiang Scholar Program of University of South China [2014-004]
  7. University of South China [2014XQD36, 2015XQD37]
  8. Graduate student innovation project of Cooperative innovation Center for Molecular Target New Drug [0223-0002-D0033]
  9. High Level Talents Aid Program in University of South China [2017-28]
  10. Major project of Nursing School of University of South China [HLPY006]

向作者/读者索取更多资源

Lipoprotein lipase (LPL) is a rate-limiting enzyme that catalyzes hydrolysis of the triglyceride (TG) core of circulating TG-rich lipoproteins including chylomicrons (CM), low-density lipoproteins (LDL) and very low density lipoproteins (VLDL). A variety of parenchymal cells can synthesize and secrete LPL. Recent studies have demonstrated that complicated processes are involved in LPL biosynthesis, secretion and transport. The enzyme activity of LPL is regulated by many factors, such as apolipoproteins, angiopoietins, hormones and miRNAs. In this article, we also reviewed the roles of LPL in atherosclerosis, coronary heart disease, cerebrovascular accident, Alzheimer disease and chronic lymphocytic leukemia. LPL in different tissues exerts differential physiological functions. The role of LPL in atherosclerosis is still controversial as reported in the literature. Here, we focused on the properties of LPL derived from macrophages, endothelial cells and smooth muscle cells in the vascular wall. We also explore the existence of crosstalk between LPL and those cells when the molecule mainly plays a proatherogenic role. This review will provide insightful knowledge of LPL and open new therapeutic perspectives.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据