期刊
CIRCULATION RESEARCH
卷 123, 期 3, 页码 326-328出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.313146
关键词
antioxidants; cardiovascular diseases; cytokines; oxygen; reactive oxygen species
资金
- Goethe-University
- Heinrich und Fritz-Riese-Stiftung
- Deutsche Forschungsgemeinschaft DFG [SCHR 1241/1-1, SFB 815, SFB 834]
Based on the concept of oxidative stress, reactive oxygen species (ROS) have been incriminated as the drivers behind almost every cardiovascular pathology. Redox alterations are, however, omnipresent bystanders to changes in cellular activity state. Even when ROS levels are altered, their contribution to pathology is not necessarily causal. Researchers should hesitate to engage in global ROS measurements and rather aim on identifying individual molecular targets of redox regulation.
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