Hyaluronan A Master Switch Between Vascular Homeostasis and Inflammation

Hyaluronan (HA) matrix responds quickly to changing conditions during atherogenesis and atheroprogression. Our evolving understanding of HA's specific functions at the interface of inflammatory responses and phenotypic control of mesenchymal cells in the vessel wall points to its importance in inflammation and atherosclerosis. Additionally, the enzymes that mediate HA biosynthesis and degradation are potential target molecules for novel therapies, as are signal-transducing HA receptors: deciphering the HA matrix, thus, has significant translational possibilities.