期刊
CHROMATOGRAPHIA
卷 81, 期 7, 页码 1063-1070出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10337-018-3528-y
关键词
Homogeneous liquid-liquid microextraction; Switchable hydrophilicity solvent; Dipropylamine; Methadone; Tramadol
资金
- Research Affairs of the University of Zabol [UOZ-GR-9517-42]
In this work, a new method based on homogeneous liquid-phase microextraction was developed for the determination of methadone and tramadol. Dipropylamine was used as extraction solvent with switchable hydrophilicity that can be miscible/immiscible upon the addition or removal of CO2 as a reagent. The effects of operational parameters of the extraction such as volume of acceptor phase, volume of donor phase, pH of donor phase, and ionic strength of solution were investigated. Under optimal conditions, the preconcentration factors, the detection limits and the linearity of the method were achieved in the ranges of 135-138, 1.2 and 4-1000 A mu g L-1, respectively. Finally, the proposed method has been successfully applied to the analysis of methadone and tramadol in urine samples. In urine sample, the preconcentration factors were 118 and 122 for methadone and tramadol, respectively. Additionally, calibration curves were found to be linear in the concentration range of 8-1000 A mu g L-1 with the r (2) values better than 0.998. In addition, limits of detection and quantification were 2.4 and 8 A mu g L-1, respectively, for both analytes.
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