期刊
CHINESE MEDICAL JOURNAL
卷 131, 期 11, 页码 1357-1364出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.4103/0366-6999.232801
关键词
Biomarker; Diabetic Kidney Disease; Diagnosis; Extracellular Vesicles; Therapy
资金
- Guangdong Provincial Science and Technology Project [2014A020212662]
- Science and Technology Planning Project of Southern Medical University [CX2016N018]
- Science and Technology Planning Project of Tianhe District, Guangzhou City [201704KW011]
- Natural Science Foundation of Guangdong Province [2016A030313559]
- South Wisdom Valley Innovative Research Team Program [CXTD-004]
Objective: Diabetic kidney disease (DKD) has become one of the major causes of end-stage renal disease. Urinary extracellular vesicles (uEVs) contain rich biological information which could be the ideal source for noninvasive biomarkers of DKD. This review discussed the potential early diagnostic and therapeutic values of proteins and microRNAs in uEVs in DKD. Data Sources: This review was based articles published in PubMed, Embase, Cochrane, and Google Scholar databases up to November 20, 2017, with the following keywords: Diabetic kidney disease, Extracellular vesicle, and Urine. Study Selection: Relevant articles were carefully reviewed, with no exclusions applied to the study design and publication type. Results: There is no gold standard technology to separate and/or purify uEVs. The uEVs contain a variety of proteins and RNAs and participate in the physiological and pathological processes of the kidney. UEVs, especially urinary exosomes, may be useful biomarkers for early diagnosis and treatment to DKD. Furthermore, the uEVs has been used as a therapeutic target for DKD. Conclusion: Proteins and nucleic acids in uEVs represent promising biomarker for the diagnosis and treatment of DKD.
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