期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 85, 期 -, 页码 71-77出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2015.08.006
关键词
Selenium; Nanoparticles; Size; Cytotoxicity; Reactive oxygen species
资金
- Specialized Research Fund for Doctoral Program of Higher Education [20123418110003]
- Funds of Anhui Provincial Science and Technology Department [1306c083018, 1408085MKL39, 1406C085017]
- Anhui Major Demonstration Project for Leading Talent Team on Tea Chemistry and Health
- Tea Project of Anhui Provincial Agriculture Committee
- Collaborative Innovation Center of Agri-forestry Industry in Dabieshan Area, Anhui Agricultural University
Elemental selenium nanoparticles (SeNPs) have been demonstrated to be equivalent to selenomethionine and methylselenocysteine in upregulating selenoenzymes; however, the toxicity of SeNPs is markedly lower than these two organic selenium compounds. The objective of this study was to determine the effect of SeNP size on cancer cell growth and ascertain whether production of reactive oxygen species (ROS) is implicated as a candidate mechanism of action. Two types of SeNPs (averaging 35 nm and 91 nm) were investigated. Cell accumulation was inhibited in vitro and in vivo in a manner inversely proportional to particle size. In vitro modeling experiments showed the reduction of SeNPs to be glutathione concentration dependent and to result in ROS formation. Both SeNP biotransformation and ROS production were size dependent, with the smaller SeNPs being more active, thereby suggesting that small-sized SeNPs are more effective in inhibiting cancer cell proliferation through an ROS mediated mechanism. (C) 2015 Elsevier Ltd. All rights reserved.
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