期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 38, 期 3, 页码 672-676出版社
SCIENCE PRESS
DOI: 10.6023/cjoc201710004
关键词
asymmetric synthesis; thienyl; aluminum; titanium; ketones
资金
- National Natural Science Foundation of China [21372009, 21672004]
The optically active diaryl alcohols bearing thienyl group are well-known for their biological activity as well as key substructure in bioactive compounds and pharmaceuticals. The asymmetric addition of 3-thienylaluminum to ketones afforded the optically active 3-thienyl arylethanols in good yields with high enantioselectivities of up to 910% ee employing the simple titanium catalytic system of (S)-1, 1'-binaphthol. The catalytic system could also suit for various ketones bearing an electron-donating or electron-withdrawing groups to afford the corresponding diarylethanols containing substituted 3-thienyl groups.
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