期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 84, 期 -, 页码 125-132出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2015.08.017
关键词
EGCG; Colon cancer; Apoptosis; p38 gamma/p38 delta; ERK; Akt
资金
- FIS Sara Borrell award from the Instituto de Salud Carlos III
- Caixa Foundation International Fellowship (la Caixa/CNB)
- Juan de la Cierva award from the Spanish Ministry of Economy and Competitiveness (MINECO)
- MINECO [BFU2007-67577, BFU2010-19734, SAF2013-45331-R]
We investigated apoptosis induced by the green tea component the epigallocatechin-3-gallate (EGCG) and the pathways underlying its activity in a colon cancer cell line. A complete understanding of the mechanism(s) and molecules targeted by green tea polyphenols could be useful in developing novel therapeutic approaches for cancer treatment. EGCG, which is the major polyphenol in green tea, has cytotoxic effects and induced cell death in HT-29 cell death. In this study, we evaluated the effect EGCG on mitogen-activated protein kinase (MAPK) and Akt pathways. EGCG treatment increased phospho-ERK1/2, -JNK1/2 and -p38 alpha, -p38 gamma and -p38 delta, as well as phospho-Alct levels. Using a combination of kinase inhibitors, we found that EGCG-induced cell death is partially blocked by inhibiting Akt, ERK1/2 or alternative p38MAPK activity. Our data suggest that these kinase pathways are involved in the anticancer effects of EGCG and indicate potential use of this compound as chemotherapeutic agent for colon cancer treatment (C) 2015 Elsevier Ltd. All rights reserved.
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