期刊
CHINESE JOURNAL OF CHEMISTRY
卷 36, 期 3, 页码 217-222出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201700633
关键词
C(sp)C(sp(3)) cross-coupling; metal carbene; asymmetric catalysis; Cu(I) catalysts; N-tosylhydrazones
资金
- National Basic Research Program of China (973 Program) [2015CB856600]
- National Natural Science Foundation of China [21472004, 21332002]
- China Postdoctoral Science Foundation Funded Project [2015M580911]
The first catalytic enantioselective C(sp)?C(sp(3)) cross-coupling reaction between N-tosylhydrazones and trialkylsilylethynes in the presence of Cu(I) salts and chiral phosphoramidite ligands was developed. A series of synthetically interesting, functionalized alkynes were obtained with moderate to good enantioselectivities (up to 83% ee). Cu(II) carbene migratory insertion is proposed to be the enantio-determining step.
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