期刊
CHINESE CHEMICAL LETTERS
卷 29, 期 1, 页码 102-106出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2017.06.013
关键词
Bisphenols; Benzophenones; Parabens; Liquid chromatography-mass spectrometry; Human urine
资金
- National Natural Science Foundation of China [21505111, 21437002, 21507106]
- Research Grants Council of Hong Kong, China [12301915, 12319716]
Bisphenols, benzophenones and parabens may alter one or more functions of endocrine system and consequently cause adverse health effects on human. A rapid and sensitive analytical method for the simultaneous determination of six bisphenols, five benzophenones and seven parabens in human urine by using ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed and applied for human urine sample analysis. The eighteen targeted compounds were separated within 11 min. Heated-electrospray ionization was operated with multiple reaction monitoring in negative-ion mode. The limit of detection ranged from 0.01 ng/mL, to 0.5 ng/mL. Seven isotope-labeled internal standards were used in the quantitative analysis. After the method was validated for sensitivity, linearity, precision, accuracy and matrix effect, it was applied for the analysis of human urine samples to evaluate the profiles of human exposure. Eight of the targeted analytes were detected in more than 50% urine samples. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据