期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 78, 期 -, 页码 116-121出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2015.02.007
关键词
Chlorella; pyrenoidosa; Toxicity; Combined effect; Cefradine; Ceftazidime; RSM
资金
- Natural Science Foundation of Jiangsu Province Youth Fund [BK20130646, BK20140653]
- Jiangsu Key Lab of Environmental Engineering Open Foundation [KF2012008]
- Doctor Scientific Research Foundation from China Pharmaceutical University [2012ZJ13002]
- National Undergraduate Training Programs for Innovation and Entrepreneurship [02640556]
- Fundamental Research Funds for the Central Universities [JKQZ2013009, JKPZ2013017, ZJ15001]
- Qing Lan Project [2014]
The present work evaluated the combined effects of cefradine and ceftazidime on the green alga Chlorella pyrenoidosa using response surface methodologies (RSM). After a 48 h-exposure, the population growth rate (PGR), the chlorophyll-a content and the SOD content of the alga increased with increased concentrations of two antibiotics. However, the three responses did not continue to demonstrate significant increases once antibiotic concentrations exceed a moderate level. Three two order polynomial regression equations were obtained to describe well the relationship between the responses of the alga and the two antibiotics' concentration (R-2= 0.9997, 0.9292 and 0.9039, respectively). Three 3 D-surface graphs and their contour plots showed directly the changing trends of the alga under the combined effects of two antibiotics. This study for the first time employed the RSM in ecotoxicology, which indicated that the RSM should be placed under a feasible and a potential application prospect in toxicity assessment. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据