Quadruple thermo-photo-redox-responsive random copolypeptide nanogel and hydrogel

A series of random copolypeptides of poly(methoxy-diethylene glycol-L-glutamate)-co-poly(S-(o-nitrobenzyl)-L-cysteine)was synthesized by ring-open copolymerization of methoxydiethylene glycol-L-glutamate-N-carboxyanhydride (EG(2)-Glu-NCA) and S-(o-nitrobenzyl)-L-cysteine-N-carboxyanhydride (NBC-NCA) in dried dimethylformamide solution, which presents quadruple thermo-photo-redox responsive self-assembly behavior and forms the related nanogel and hydrogel in water. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.