期刊
CHINESE CHEMICAL LETTERS
卷 30, 期 2, 页码 470-472出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2018.04.013
关键词
Mixed-mode; Stationary phase; Reversed phase liquid chromatography; Hydrophilic interaction liquid chromatography; Ion exchange; Drug molecules
资金
- National Natural Science Foundation of China [21477037, 21322502]
- Outstanding Young Talent Cultivation Fund of East China University of Science and Technology
A reversed phase (RP)/hydrophilic interaction (HILIC)/ion exchange (IEX) mixed tri-mode stationary phase (TMSP) has been prepared via a divergent synthesis scheme starting from propylamine on silica then by amine-epoxy reactions with 1,4-butanedioldiglycidyl ether and tertiary amines (N,N-dimethyldecylamine, DMDA). Its retention mechanism was found to follow RP/HILIC/IEX mixed-mode. The stop-flow test revealed that TMSP had good compatibility with 100% aqueous mobile phase. It demonstrated effective separation towards several kinds of compounds or drug molecules and their counterions within a single run. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据