期刊
CHINESE CHEMICAL LETTERS
卷 29, 期 2, 页码 267-270出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2017.10.007
关键词
Fluorescent imaging; Sulfur speciation; Subcellular localization; Sulfonium; Mitochondria targeting; Electrostatic surface potential
资金
- National Key Basic Research Support Foundation of China [2015CB856301]
- National Natural Scientific Foundation of China [21571007, 21271013, 21321001]
Targeted-delivery is of great importance to molecular probes and drugs for cell biology study. Herein we reported 11 sulfur-containing coumarins as cell imaging probes. Different sulfur speciation of the 4 representative coumarins SC1-SC4 renders them significantly different subcellular localizations and cellular uptake pathways: SC1 containing thioether group located in lysosomes, while sulfoxide and sulfone compounds SC2 and SC3 distributed in the whole cell. Furthermore, the cationic sulfonium containing compound SC4 was internalized by clathrin-mediated endocytosis and localized at mitochondria. By analyzing the molecular parameters of all 11 coumarins, we found that different sulfur speciation affected their lipophilicity and electrostatic surface potential. These two key factors play roles in altering biological behaviors of the coumarins. The results revealed the importance of sulfur speciation on the physicochemical properties and thus subcellular localization of bioprobes. This is useful for designing new functional bioprobes. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据