Room temperature multicomponent synthesis of diverse propargylamines using magnetic CuFe2O4 nanoparticle as an efficient and reusable catalyst

Copper ferrite (CuFe2O4) nanoparticles catalyzed room temperature multicomponent reaction of aliphatic amines, formaldehyde, arylboronic acids and alkynyl carboxylic acids was reported for the synthesis of diverse propargylamines with good to excellent yields. The catalyst can be magnetically recovered and reused at least five times without significant loss of activity. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.