期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 40, 页码 10128-10135出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800500
关键词
nanostructures; nucleic acids; peptide conjugates; systems chemistry
资金
- NSF-BSF grant [2015671]
- COST actions [CM1304, TD1308]
- Direct For Mathematical & Physical Scien [1610377] Funding Source: National Science Foundation
Striking synergy between nucleic acids and proteins is exhibited in living cells. Whether such mutual activity can be performed using simple supramolecular nucleic acid-peptide (NA-pep) architectures remains a mystery. To shed light on this question, we studied the emergence of a primitive synergy in assemblies of short DNA-peptide chimeras. Specifically, we characterized multiple structures forming along gradual mixing trajectory, in which a peptide solution was seeded with increasing amounts of NA-pep chimeras. We report on the systematic change from -sheet-peptide-based fibrillar architectures into the spherical structures formed by the conjugates. Remarkably, we find that through forming onion-like structures, the conjugates exhibit increased DNA hybridization stability and bind small molecules more efficiently than the peptides or DNA alone. A brief discussion highlights the implications of our findings for the production of new materials and for research on the origin of life.
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