期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 40, 页码 10224-10230出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201801725
关键词
antioxidant machinery; enzymes; nanozymes; reactive oxygen species; self-assembly
资金
- National Natural Science Foundation of China [21431007, 21403209, 21533008, 21673223, 21601175]
- Key Program of Frontier of Sciences, CAS [QYZDJ-SSW-SLH052]
A self-assembly nanocomposite was designed to mimic intracellular enzymatic and non-enzymatic antioxidants-constituted antioxidant defense machinery. In this work, selenium nanocomponent served as one model to mimic antioxidant enzyme, whereas polydopamine was able to mimic non-enzymatic antioxidant biomolecule in living systems. With the excellent glutathione peroxidase-mimic capacity of selenium and the reducibility of polydopamine, this Se@pDA nanozyme could achieve synergetic antioxidative efficiency to protect cellular components against oxidative damage. The pneumonia model of mice further proved the potential of our nanocomposites for anti-inflammation therapy.
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