期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 47, 页码 12241-12245出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800993
关键词
biosensors; carbon; coiled coil; nanotubes; peptides
资金
- DFG (Deutsche Forschungsgemeinschaft)
- VW foundation
- state of Lower Saxony (life@nano)
- Cluster of Excellence
- DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain
- FCI (Fonds der chemischen Industrie)
Specific functionalization of 1D nanomaterials such as near infrared (nIR) fluorescent single-walled carbon nanotubes (SWCNTs) is essential for colloidal stability and tailoring of their interactions with the environment. Here, we show that de novo designed alpha-helical coiled-coil peptide barrels (HBs) with appropriate pores encapsulate and solubilize SWCNTs. In contrast, barrels without or with narrow pores showed a much smaller efficiency. Absorption/fluorescence spectroscopy and atomic force microscopy indicate that the SWCNTs are incorporated into the HBs pore. The resulting hybrid SWCNT@alpha HBs display periodic surface coverage with a 40 nm pitch and remain fluorescent in the nIR. This approach presents a novel concept to encapsulate, discriminate and functionalize SWCNTs non-covalently with peptides and holds great promise for future applications in bioimaging or drug delivery.
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