期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 29, 页码 7345-7348出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201801138
关键词
degradable material; dynamic covalent chemistry; dynamic hindered urea; pH independency
资金
- National Science Foundation [CHE 15-08710]
- Beckman Institute Graduate Fellowship at the University of Illinois at Urbana-Champaign
- Arnold and Mabel Beckman Foundation
- Direct For Mathematical & Physical Scien [1508710] Funding Source: National Science Foundation
Low cost, high performance hydrolysable polymers are of great importance in biomedical applications and materials industries. While many applications require materials to have a degradation profile insensitive to external pH to achieve consistent release profiles under varying conditions, hydrolysable chemistry techniques developed so far have pH-dependent hydrolytic kinetics. This work reports the design and synthesis of a new type of hydrolysable polymer that has identical hydrolysis kinetics from pH3 to 11. The unprecedented pH independent hydrolytic kinetics of the aryl ureas were shown to be related to the dynamic bond dissociation controlled hydrolysis mechanism; the resulting hindered poly(aryl urea) can be degraded with a hydrolysis half-life of 10min in solution. More importantly, these fast degradable hindered aromatic polyureas can be easily prepared by addition polymerization from commercially available monomers and are resistant to hydrolysis in solid form for months under ambient storage conditions. The combined features of good stability in solid state and fast hydrolysis at various pH values is unprecedented in polyurea material, and will have implications for materials design and applications, such as sacrificial coatings and biomaterials.
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