期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 25, 页码 6547-6550出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201801312
关键词
allenic amine; indole alkaloid; oxidative cyclization; pyrrolidine ring; ring-expansion
资金
- Chinese Academy of Sciences (Strategic Priority Research Program) [XDB20020200, QYZDJ-SSW-SLH029]
- National Natural Science Foundation of China [21132008]
A novel manganese(III)-mediated oxidative cyclization of readily accessible 1,2,3-trisubstituted indoles is described. This unprecedented method enabled the efficient construction of a complex polycyclic scaffold bearing a spiro-indoline motif and a lactone moiety in one step. Its synthetic utility was demonstrated in the total synthesis of lapidilectineB (in 18 steps) by employing a strategic regioselective ring-expansion and a silver-promoted allenic amine cyclization as the additional key elements.
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