期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 43, 页码 11177-11184出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201801854
关键词
biosensors; electrochemistry; gold; tin; surface chemistry
资金
- Sorbonne Universite
- CNRS
- LabEx MiChem part of French state [ANR-11-IDEX-0004-02]
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [659211]
- Marie Curie Actions (MSCA) [659211] Funding Source: Marie Curie Actions (MSCA)
Self-assembled monolayers formed by chemisorption of thiolated molecules on gold surfaces are widely applied for biosensing. Moreover, and due to the low stability of thiol-gold chemistry, contributions to the functionalisation of gold substrates with linkers that provide a more stable platform for the immobilisation of electroactive or biological molecules are highly appreciated. Herein, it is demonstrated that a carboxylated organotin compound can be successfully grafted onto gold substrates to form a highly stable organic layer with reactivity for subsequent binding to an aminated molecule. A battery of techniques were used to characterise the surface chemistry. The grafted layer was used to anchor aminoferrocene and subjected to both thermostability tests and long-term stability studies over a period of one year, demonstrating thermostability up to 90 degrees C and storage stability for at least 12 months at 4 degrees C protected from light. The stable surface tethering of molecules on gold substrates can be exploited in a plethora of applications, including molecular techniques, such as solid-phase amplification and solid-phase melting curve analysis, that require elevated temperature stability, as well as biosensors, which require long-term storage stability.
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