期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 46, 页码 11840-11851出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800981
关键词
antitumor agents; bioinorganic chemistry; cancer; gold; pincer ligands
资金
- European Research Council
- ERC Advanced Investigator Award [338944-GOCAT]
Gold(III) complexes have emerged as a versatile and effective class of metal-based anticancer agents. The development of various types of ligands capable of stabilizing the Au-III cation and preventing its reduction under physiological conditions, such as chelating nitrogen-donors, dithiocarbamates and C<^>N cyclometalled ligands, has opened the way for the exploration of their potential intracellular targets and action mechanisms. At the same time, the bioconjugation of Au-III complexes has emerged as a promising strategy for improving the selectivity of this class of compounds for cancer cells over healthy tissues, and recent developments have shown that combining gold complexes with molecular structures that are specifically recognized by the cell can exploit the cell's own transport mechanisms to improve selective metal uptake.
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